Robust estimation with platform-trial drift and adaptive allocation: predictable scores under unrestricted time drift
Scope
For prespecified nonnegative weights summing to one, the concurrent target comparing arm $j$ to control is \[
\Delta_j(a)=\sum_{i=1}^n a_i\{m_j(X_i,t_i)-m_0(X_i,t_i)\}.
\] The platform-trial discussion in Section 3.1.3 of [agenda] emphasizes adaptive allocation and secular drift. The results below condition on a fixed covariate and time sequence, as allowed by the independent-arrival submodel, and keep allocation probabilities predictable. They give finite-sample protection against drift and quantify the bias--variance cost of borrowing historical controls.
Proposition (A martingale interval with arbitrary drift): Let $|Y_i|\le1$. Conditional on fixed covariates and times, suppose assignment probabilities $q_{ia}$ are measurable before observation $i$, satisfy $q_{ij},q_{i0}\ge\epsilon$, and sequential randomization gives $E[Y_i\mid\mathcal F_{i-1},W_i=a]=m_a(X_i,t_i)$. Define \[
S_{ij}=\frac{1\{W_i=j\}Y_i}{q_{ij}}-
\frac{1\{W_i=0\}Y_i}{q_{i0}},\qquad
\widehat\Delta_j=\sum_i a_iS_{ij}.
\] Then $E(\widehat\Delta_j-\Delta_j)^2\le v$, where $v=2\epsilon^{-1}\sum_i a_i^2$. Put $b=3\epsilon^{-1}\max_i a_i$ and $x=\log(2/\alpha)$. The interval with center $\widehat\Delta_j$ and radius $\sqrt{2vx}+2bx/3$ has coverage at least $1-\alpha$, uniformly over the time functions $m_a$.
Proof: The errors $D_i=a_i\{S_{ij}-(m_j-m_0)(X_i,t_i)\}$ are martingale differences. Since the two arm indicators are disjoint, $E[S_{ij}^2\mid\mathcal F_{i-1}]\le1/q_{ij}+1/q_{i0}\le2/\epsilon$. Thus the predictable sum of conditional variances is at most $v$, and $|D_i|\le a_i(1/\epsilon+2)\le b$. Orthogonality of martingale differences proves the mean-square bound.
For completeness, expansion of the conditional exponential and the inequalities $E[D_i\mid\mathcal F_{i-1}]=0$ and $E|D_i|^k\le b^{k-2}E[D_i^2\mid\mathcal F_{i-1}]$ give, for $0<\lambda<3/b$, \[
E[e^{\lambda D_i}\mid\mathcal F_{i-1}]
\le\exp\left\{\frac{\lambda^2E[D_i^2\mid\mathcal F_{i-1}]}{2(1-\lambda b/3)}\right\}.
\] Here $k!\ge2\cdot3^{k-2}$ for $k\ge2$ bounds the Taylor series. Iteration and Markov's inequality yield $P(\sum_iD_i\ge z)\le\exp\{-z^2/[2(v+bz/3)]\}$. The stated radius is at least the positive solution of $z^2=2x(v+bz/3)$. Apply the same argument to $-D_i$ and union bound. ∎
This result uses a fixed weighted target. Weights depending on future outcomes would generally destroy predictability. Conditioning on all covariates is justified only if future covariates do not reveal past structural errors; fixed covariates or independent arrivals satisfy this restriction.
Proposition (Predictable augmentation and its exact bias): Let $\widehat m_{ia}$ and $\widehat q_{ia}\ge\epsilon$ be predictable, with the mean estimates bounded. For \[
T_{ia}=\widehat m_{ia}+\frac{1\{W_i=a\}}{\widehat q_{ia}}
(Y_i-\widehat m_{ia}),
\] the conditional bias relative to $m_{ia}$ is \[
E[T_{ia}\mid\mathcal F_{i-1}]-m_{ia}
=\left(1-\frac{q_{ia}}{\widehat q_{ia}}\right)(\widehat m_{ia}-m_{ia}).
\] For the arm contrast the absolute weighted bias is at most \[
\epsilon^{-1}\sum_i a_i\sum_{a\in\{0,j\}}
|\widehat q_{ia}-q_{ia}|\,|\widehat m_{ia}-m_{ia}|.
\]
Proof: Conditional randomization gives $E[1\{W_i=a\}(Y_i-\widehat m_{ia})\mid\mathcal F_{i-1}]
=q_{ia}(m_{ia}-\widehat m_{ia})$. Substitution proves the identity; the denominator lower bound and triangle inequality prove the contrast bound. With the actual known randomization probabilities, the bias is exactly zero even if the outcome regressions are wrong. If regressions use the same current outcome without a valid independence or predictability argument, this calculation does not apply. ∎
For balanced weights $a_i=1/n$, the $1/(n\epsilon)$ risk dependence is unavoidable in a constant-mean submodel: take $q_{ij}=\epsilon$ and vary only a Bernoulli mean in arm $j$ by $\pm c/\sqrt{n\epsilon}$. The total relative entropy is bounded, and target separation is of that order. For $n\epsilon$ bounded, fixed interior mean differences give a constant lower bound. Thus the lower bound is $c\min\{1,(n\epsilon)^{-1}\}$. This argument does not establish optimality of arbitrary prescribed weights under additional pooling restrictions.
Proposition (How much historical borrowing is defensible): Let $C$ be an unbiased estimator of a current control mean, with variance at most $v_C$. Let $H$ be independent of $C$, with variance at most $v_H$ and bias of absolute value at most $b_H$. Then the estimator $(1-\lambda)C+\lambda H$ has mean squared error at most \[
(1-\lambda)^2v_C+\lambda^2(v_H+b_H^2).
\] For $v_C+v_H+b_H^2>0$ this bound is minimized on $[0,1]$ by $\lambda=v_C/(v_C+v_H+b_H^2)$.
Proof: Independence makes the variance the sum of the two weighted variances, and only $H$ contributes bias, of magnitude at most $\lambda b_H$. Differentiate the displayed convex quadratic to obtain its minimizer, which belongs to $[0,1]$. ∎
For a time mean satisfying $|m(t)-m(s)|\le L|t-s|^u$, $0<u\le1$, historical and current point times separated by $g$ give $b_H\le Lg^u$. For weighted time distributions any coupling gives the more general bound $L E|T_H-T_C|^u$. When $Lg^u\le2$, the bounded mean $m(t)=\min\{1,-1+L|t-t_C|^u\}$ attains the point-time bound. It remains $u$-Holder with constant $L$ because truncation is nonexpansive. Thus smoothness alone does not eliminate the drift allowance.
Remaining gap
The note does not optimize adaptive recruitment or borrowing when drift smoothness, nuisance quality, and variance are all unknown. Historical and current estimates in the last proposition are independent by assumption; the original adaptive platform requires handling their actual dependence. Sharp minimax rates exploiting smooth drift, and efficient simultaneous arm comparisons with estimated nuisance functions, remain unresolved.
Completion Estimate
50%
This is a post hoc, heuristic estimate for the full catalogue target. The attempt establishes drift-uniform martingale inference, exact predictable augmentation bias, an overlap lower bound and a historical-control borrowing calculation. Sharp smooth-drift minimax precision and optimal dependent pooling or adaptive recruitment with learned nuisance functions remain unresolved for the full platform-trial class.
References
- [agenda] C. Cinelli, A. Feller, G. Imbens, E. Kennedy, S. Magliacane, and J. Zubizarreta. Challenges in Statistics: A Dozen Challenges in Causality and Causal Inference (2025). https://arxiv.org/html/2508.17099v1.