Computational biology

The Top Open Problems editorial order restricted to Computer Science, followed by cross-listed economics entries. Existing relative order is retained, with provisional placements for new game-learning questions; most entries have no individual difficulty assessment. About rankings

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CS-208 Simultaneously certified invariant quartet scoring and robust assembly Partially solved · LLM status: Open · 1 attempt · 2026-10-11
CS-209 Root obstruction and outgroup-oriented algebraic clade certificates Partially solved · LLM status: Open · 1 attempt · 2026-10-11
CS-488 Vertex flattenings generate the phylogenetic ideal Solved · LLM status: Solved · 1 attempt · 2026-10-11
CS-489 The stochastic image of a binary phylogenetic tripod Partially solved · LLM status: Open · 1 attempt · 2026-10-11
CS-490 Generator-invariant local efficacy for phylogenetic invariants Partially solved · LLM status: Open · 1 attempt · 2026-10-11
CS-491 A joint tree and JC69/K80 selector with a finite-sample certificate Partially solved · LLM status: Open · 1 attempt · 2026-10-11
CS-753 Unique Genome Reconstruction from Seven Beads Open · LLM status: Open · 1 attempt · 2026-10-11
CS-756 Reconstruction of Chromosome Structure from Contact Maps Partially solved · LLM status: Open · 1 attempt · 2026-10-11