Biology
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Provisional difficulty based on formal or inferential difficulty, evidence and identification, mechanistic or computational integration, and independent validation or transfer. About rankings
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- BIO-101 Germinal-centre affinity maturation
- BIO-102 Duration of immune memory
- BIO-103 Nervous-system and cancer interactions
- BIO-104 Rewiring cancer cells: abstract state-transition limits
- BIO-105 Cancer cachexia
- BIO-106 ecDNA generation and function
- BIO-107 Time-dependent tumour microenvironment
- BIO-108 Inflammation-to-cancer causality
- BIO-109 Context independence
- BIO-110 Evolutionary stability of engineered functions
- BIO-111 Scaling genetic circuits
- BIO-112 Spatial confinement of gene drives
- BIO-113 Autonomous design–build–test–learn
- BIO-114 Comparative biological timing under explicit phase conventions
- BIO-115 Molecular mechanism of animal magnetoreception
- BIO-116 How animals construct navigation maps
- BIO-117 Biological function of dreaming
- BIO-118 Intrinsically disordered protein ensembles
- BIO-119 Macromolecular crowding in vivo
- BIO-120 Cytoskeletal mechanics to cell shape
- BIO-121 Rare-versus-common variant architecture
- BIO-122 Enhancer–promoter assignment
- BIO-123 Functional transcript-isoform map
- BIO-124 Transposable-element control and function
- BIO-125 Dynamic metabolic control
- BIO-126 Emergent homeostasis
- BIO-127 Cellular resource allocation
- BIO-128 Multi-omics integration
- BIO-129 Principled model reduction for living systems
- BIO-130 Computational protein-function prediction
- BIO-131 Horizontal-gene-transfer reconstruction
- BIO-132 Three-dimensional tissue reconstruction
- BIO-133 Ion-channel gating
- BIO-134 Collective cytoskeletal force generation
- BIO-135 Thermodynamics of biomolecular phase separation
- BIO-136 Hydration contribution to biomolecular stability
- BIO-137 Mechanochemical coupling
- BIO-138 DNA-supercoiling regulation
- BIO-139 Representation drift
- BIO-140 Motor-control objective
- BIO-141 Patterning robustness
- BIO-142 Cell-fate landscape
- BIO-143 Organ-size stopping rule
- BIO-144 Positional information encoding
- BIO-145 Developmental plasticity
- BIO-146 Stem-cell niche control
- BIO-147 Developmental canalisation
- BIO-148 Evolution of developmental programmes
- BIO-149 Maintenance of recombination
- BIO-150 Genetic architecture of Haldane's rule