## Problem 267 — rank:8

**Title:** Whole-genome design

**Added binding assumptions (LaTeX):**

```latex
Define the phenotype vector as population means, distributions or specified assay summaries, with simultaneous uncertainty across the environmental panel. Sustained viability over passages needs an explicit functional-retention event or rate, not only initial growth. The finite search is in principle enumerable; the residual question is a sample-efficient, biologically validated predictive model and whether the target is feasible under the actual genome and resource constraints.
```

**Direct edits:** 0. **Fresh external checks:** None; supplied sources retained as provenance.