## Problem 258 — rank:42

**Title:** Tumour vaccinology

**Added binding assumptions (LaTeX):**

```latex
The displayed minimum over HLA strata is robustness across those strata, not automatically robustness to uncertainty in recognition probabilities. Include a joint confidence or sensitivity set when the latter is claimed. Fix clone weights, or use stratum-specific weights if composition differs by stratum. The cross-reactivity sum is a conservative union-bound constraint only for calibrated compatible event probabilities; finite assay coverage does not establish absence of untested tissue effects.
```

**Direct edits:** 0. **Fresh external checks:** None; supplied sources retained as provenance.