## Problem 032 — rank:21

**Title:** Three-dimensional genome function

**Added binding assumptions (LaTeX):**

```latex
The intervention contrast is the total effect of the architectural perturbation. It is not, by definition, the effect mediated by contact changes, because the perturbed factor can act directly on transcription. State an intervention on a manipulable mediator or an identified mediation functional before claiming an architecture-specific effect. Specify the common time grid and measurement law for contact histories.
```

**Direct edits:** 0. **Fresh external checks:** None; supplied sources retained as provenance.