## Problem 260 — rank:44

**Title:** Therapeutically targeting MYC

**Added binding assumptions (LaTeX):**

```latex
Define the growth functional for a time-varying schedule, for example a specified finite-horizon log-growth rate or an asymptotic exponent for repeated exposure. The two are not interchangeable. Specify how normal-tissue growth enters the toxicity functional and give the observation horizon. Negative mean net growth does not by itself establish finite-time extinction or a uniform recurrence bound in a heterogeneous population.
```

**Direct edits:** 0. **Fresh external checks:** None; supplied sources retained as provenance.