## Problem 030 — rank:57

**Title:** Structural-variant phenotypic effects

**Added binding assumptions (LaTeX):**

```latex
Define every $\Delta$ relative to the same sequence-resolved reference genome and matched environment. The weight matrix $W$ is fixed and positive semidefinite; to call $\|\cdot\|_W$ a norm, require positive definiteness. Because the displayed bound concerns expression only, add separate prespecified loss bounds for phenotype and any claimed dosage/contact outputs. Agreement in expression is not by itself phenotype prediction.
```

**Direct edits:** 0. **Fresh external checks:** None; supplied sources retained as provenance.