## Problem 280 — rank:46

**Title:** Safety of AI-designed genomes

**Added binding assumptions (LaTeX):**

```latex
Include randomness in the training sample and the new design, with an explicit independence or adaptive-selection law. The displayed guarantee is marginal over designs and does not imply conditional coverage for every genome or for the accepted subset. To avoid vacuous reject-all performance, fix a minimum acceptance rate where feasible and separately bound false acceptance among accepted designs. No claim extends to unspecified hazards or arbitrary unsupported environmental shifts.
```

**Direct edits:** 0. **Fresh external checks:** None; supplied sources retained as provenance.