## Problem 295 — rank:2

**Title:** RNA-to-protein transition

**Added binding assumptions (LaTeX):**

```latex
The path probability needs a complete population-level mutation, reproduction and fixation process, not only a graph of chemically possible steps. State the common environmental conditions for comparing initial and final fitness, and the resource investment assigned to each intermediate. Sequence-dependent peptide output must exceed a declared nonspecific-production baseline. Accessibility, chemical continuity and evidence that the path occurred historically remain distinct claims.
```

**Direct edits:** 0. **Fresh external checks:** None; supplied sources retained as provenance.