## Problem 041 — rank:4

**Title:** Predictive whole-cell modelling

**Added binding assumptions (LaTeX):**

```latex
The readout-specific tolerance is inside the maximum after normalization, as corrected below. Each $\widehat h_{j,u}$ is a specified model mean, trajectory summary or distributional functional, and its norm and time grid are fixed. Interfaces must conserve the same molecular accounting units. Matching means alone does not certify variability, joint correlations or rare cell failures.
```

**Direct edits:** 1. **Fresh external checks:** None; supplied sources retained as provenance.