## Problem 029 — rank:56

**Title:** Predicting de-novo mutation effects

**Added binding assumptions (LaTeX):**

```latex
The coverage probability includes training-data randomness and a fresh test variant from the declared validation distribution. This is marginal coverage, not coverage for each fixed mutation or arbitrary distribution shift. Report coverage and interval width jointly on the nonabstaining subset, with a minimum coverage fraction; otherwise abstention can make apparent success vacuous.
```

**Direct edits:** 0. **Fresh external checks:** None; supplied sources retained as provenance.