## Problem 274 — rank:45

**Title:** Predictable mammalian gene circuits

**Added binding assumptions (LaTeX):**

```latex
Fix the initial clone distribution and stochastic observation law for every input and cell context. A finite panel cannot certify a continuum of inputs without a response-regularity and coverage bound. State whether failure is evaluated at one time or anywhere during the passage horizon, and include silencing as an explicit failure state. Hold-out integration sites and cell types must not be used for normalization fitting.
```

**Direct edits:** 0. **Fresh external checks:** None; supplied sources retained as provenance.