## Problem 282 — rank:188

**Title:** Prebiotic synthesis network

**Added binding assumptions (LaTeX):**

```latex
Restrict candidate networks to a stated, empirically supported reaction library and count all catalysts and external processing steps. Enforce elemental and charge balance in addition to the displayed species balance, with positivity-preserving feed/loss kinetics and initial concentrations. Define the nonzero parameter neighborhood in physical units and require the target throughout it. A synthetic existence pathway does not by itself identify the historical pathway on Earth.
```

**Direct edits:** 0. **Fresh external checks:** None; supplied sources retained as provenance.