## Problem 285 — rank:47

**Title:** Pre-RNA heredity

**Added binding assumptions (LaTeX):**

```latex
Specify the sequence-dependent offspring law behind aggregate production and degradation rates, and the founder sequence distribution used for mutual information. Positive mean production minus loss does not ensure preservation of functional sequence information. Define the RNA-transition event, time horizon and background-contamination model. Demonstrated heredity in an engineered non-RNA chemistry must be distinguished from a pathway satisfying the stated geochemical restrictions.
```

**Direct edits:** 0. **Fresh external checks:** None; supplied sources retained as provenance.