## Problem 093 — rank:71

**Title:** Physical origin of enzyme-rate enhancement

**Added binding assumptions (LaTeX):**

```latex
Compare rate constants of the same reaction order and concentration convention; catalytic turnover and a bimolecular uncatalyzed rate cannot be directly ratioed without standard-state factors. The Eyring expression presumes the chosen activated-rate model, while recrossing and quantum corrections must be consistently assigned. Nonunique energetic decompositions require explicitly defined perturbation or alchemical contrasts.
```

**Direct edits:** 0. **Fresh external checks:** None; supplied sources retained as provenance.