## Problem 096 — rank:72

**Title:** Nucleosome positioning from sequence and activity

**Added binding assumptions (LaTeX):**

```latex
Choose an exact integer footprint and permitted boundary configurations rather than an approximate exclusion rule. The displayed $o_i$ is start-site occupancy; base coverage is the sum of start occupancies whose footprints cover that base. Fix histone insertion/removal reservoirs, the initial distribution and remodeler fuel conditions. Equilibrium energies alone do not determine active repositioning kinetics.
```

**Direct edits:** 0. **Fresh external checks:** None; supplied sources retained as provenance.