## Problem 250 — rank:38

**Title:** Normal tissues carrying oncogenic mutations

**Added binding assumptions (LaTeX):**

```latex
Fix the prediction time origin, baseline normal-histology criterion and clone-sampling process. If clone size and tissue state evolve, either condition on baseline covariates in a declared reduced hazard model or supply their joint time-dependent law. A risk superlevel set is an operational classification region, not a deterministic transition surface. Report competing-risk uncertainty and lack of support for unseen clone/context combinations.
```

**Direct edits:** 0. **Fresh external checks:** None; supplied sources retained as provenance.