## Problem 230 — rank:253

**Title:** Lysosomal permeabilization and cell-death ordering

**Added binding assumptions (LaTeX):**

```latex
Call this a controlled trajectory-intervention contrast, not a natural path-specific mediation effect. State which remaining structural equations are left unchanged and how latent death commitment evolves after the substitution. Reporter delays and sampling resolution constrain temporal ordering separately from causal identification. Admissible paths must satisfy the declared state constraints; mathematical path substitution is not evidence that a biological intervention realizing it is available.
```

**Direct edits:** 1. **Fresh external checks:** None; supplied sources retained as provenance.