## Problem 227 — rank:100

**Title:** Is dysbiosis cause or consequence?

**Added binding assumptions (LaTeX):**

```latex
Setting one log-ratio coordinate requires a declared complete composition, absolute-load convention and feasible intervention version; identical log ratios can accompany different microbial loads. Specify the post-intervention evolution of other coordinates and host covariates rather than conditioning on downstream mediators. Temporal precedence alone cannot distinguish reciprocal causation from latent common drivers with delays. Effects are model-defined sensitivity targets where no supported intervention exists.
```

**Direct edits:** 0. **Fresh external checks:** None; supplied sources retained as provenance.