## Problem 263 — rank:183

**Title:** Host burden prediction

**Added binding assumptions (LaTeX):**

```latex
A fractional burden can be negative if a construct improves growth; do not constrain it to $[0,1]$ without an explicit restricted hypothesis. Bound the positive reference growth rate away from zero for uniform ratio precision. Define a separate host-capacity observable and error target, because the displayed burden interval alone does not validate capacity prediction. Transfer uncertainty includes product-specific toxicity absent from the resource-allocation model.
```

**Direct edits:** 0. **Fresh external checks:** None; supplied sources retained as provenance.