## Problem 138 — rank:234

**Title:** Germline specification

**Added binding assumptions (LaTeX):**

```latex
Use pretreatment cellular covariates and an explicit intervention history for specification signals. Define functional germline competence by a declared later assay and time horizon, with lineage provenance and survival tracked. A competence classifier must improve on a no-covariate baseline as well as be calibrated. Separate initial competence, inducible competence and actual realized germline fate.
```

**Direct edits:** 0. **Fresh external checks:** None; supplied sources retained as provenance.