## Problem 233 — rank:101

**Title:** Germinal-centre affinity maturation

**Added binding assumptions (LaTeX):**

```latex
Specify whether $Q$ is a stochastic offspring-state matrix per division or a continuous-time mutation generator, and give the complete offspring law when lineage fluctuations are predicted. Affinity, breadth and autoreactivity scores use fixed assays and weights across lineages. The Pareto set depends on an explicitly bounded feasible model or policy class; it is not the convex hull of arbitrary measured score triples by definition.
```

**Direct edits:** 0. **Fresh external checks:** None; supplied sources retained as provenance.