## Problem 149 — rank:150

**Title:** Genetic architecture of Haldane's rule

**Added binding assumptions (LaTeX):**

```latex
Declare the feature basis, interaction order and parameter constraints for hybrid fitness, including reciprocal-cross and sex-specific states. Parent-normalized reproductive fitness is positive but can exceed one; do not silently force all interactions to be deleterious unless that restricted model is intended. Genealogical and ancestry uncertainty propagate into the inferred incompatibility network. Prediction of withheld crosses, not an arbitrary factorization of fitted fitness, is the biological criterion.
```

**Direct edits:** 0. **Fresh external checks:** None; supplied sources retained as provenance.