## Problem 034 — rank:123

**Title:** Functional transcript-isoform map

**Added binding assumptions (LaTeX):**

```latex
Specify a feasible compensation protocol: increasing one isoform cannot keep both every other isoform and their total abundance fixed. Define the baseline as the matched control under the same protocol, with $d$ restricted so all abundances remain nonnegative. Isoform abundance interventions and splice-site edits are distinct interventions unless their other effects are shown equivalent.
```

**Direct edits:** 0. **Fresh external checks:** None; supplied sources retained as provenance.