## Problem 022 — rank:17

**Title:** Functional-regulatory genome map

**Added binding assumptions (LaTeX):**

```latex
Define $\tau_{e,Y,c}$ by replacing $X_p$ with $Y$ in the intervention contrast, and hold the intervention version, reference genotype and observation time fixed. Expression and phenotype thresholds have their respective units. FDR refers to the composite threshold null, not merely a zero-effect test; detecting effects beyond a biological threshold requires uncertainty intervals that exclude that threshold.
```

**Direct edits:** 0. **Fresh external checks:** None; supplied sources retained as provenance.