## Problem 015 — rank:213

**Title:** Function of uncharacterised proteins

**Added binding assumptions (LaTeX):**

```latex
Calibration is evaluated conditionally on context and nonabstention, in prespecified bins with positive probability. A constant base-rate predictor can be perfectly calibrated, so require a nontrivial proper-score improvement or accuracy target in addition to coverage. Validation labels must be experimentally ascertained, or their missingness/detection model must justify the score; unknown functions are not automatic negatives.
```

**Direct edits:** 0. **Fresh external checks:** None; supplied sources retained as provenance.