## Problem 121 — rank:5

**Title:** From genome to organismal shape

**Added binding assumptions (LaTeX):**

```latex
Define the registered shape distance by minimizing over a declared rigid-motion group, and state whether material landmarks prevent reflections or arbitrary realignment. Hausdorff distance alone need not preserve tissue topology, so add a topology or landmark criterion when it is part of the phenotype. Fix maternal and environmental initial-condition laws and test one shared model on the specified regulatory allele panel, not every possible genome.
```

**Direct edits:** 0. **Fresh external checks:** None; supplied sources retained as provenance.