## Problem 033 — rank:122

**Title:** Enhancer–promoter assignment

**Added binding assumptions (LaTeX):**

```latex
Define precision as $|\widehat E_c\cap E_c^*|/|\widehat E_c|$ and recall as $|\widehat E_c\cap E_c^*|/|E_c^*|$ when their denominators are positive. Empty truth or prediction sets require explicit reporting, not a silently perfect score. The benchmark must sample edges and nonedges with known inclusion probabilities, and thresholded ground truth must include uncertainty near $\delta$.
```

**Direct edits:** 0. **Fresh external checks:** None; supplied sources retained as provenance.