## Problem 095 — rank:138

**Title:** DNA-supercoiling regulation

**Added binding assumptions (LaTeX):**

```latex
Define the topological closure or end constraints before applying $Lk=Tw+Wr$. The torque equation is a phenomenological closure requiring an elastic torque--twist/writhe relation, initial torsion and boundary fluxes. Specify how polymerase and topoisomerase events enter the signed source and relaxation terms. Local torque is not an independently assignable linking number at every genomic position.
```

**Direct edits:** 0. **Fresh external checks:** None; supplied sources retained as provenance.