## Problem 222 — rank:249

**Title:** Dependence of adaptive immunity on ILC activation

**Added binding assumptions (LaTeX):**

```latex
A pathway-necessity claim is not a claim that the pathway alone is sufficient, and a positive mean facilitation effect does not imply necessity. Use the same pretreatment context population in both potential-outcome laws and specify the compensation horizon. Require simultaneous uncertainty control over the declared finite context set, or regularity for a continuum. Measurement-defined success thresholds remain fixed across contexts after calibration.
```

**Direct edits:** 0. **Fresh external checks:** None; supplied sources retained as provenance.