## Problem 110 — rank:79

**Title:** Connectome-to-dynamics map

**Added binding assumptions (LaTeX):**

```latex
Hidden linear state-space realizations are generally identifiable only up to similarity transforms $x\mapsto Tx$ unless physiological measurements anchor the state coordinates. Impose observability, excitation and input calibration for the claimed coupling recovery. Anatomy can constrain zeros but does not determine sign, gain or operating-state dependence. Use a quotient target where unanchored transformations remain.
```

**Direct edits:** 0. **Fresh external checks:** SC06