## Problem 089 — rank:69

**Title:** Chromosome mechanics and condensation

**Added binding assumptions (LaTeX):**

```latex
Interpret the displayed stochastic dynamics on a specified finite bead discretization, with a standard Brownian vector and constant symmetric positive-definite mobility. State-dependent mobility requires the appropriate thermal drift, and a continuum limit requires a separate well-posed SPDE formulation. Specify how self-avoidance coexists with permitted topoisomerase strand-passage events and which topological quantities those events change.
```

**Direct edits:** 0. **Fresh external checks:** None; supplied sources retained as provenance.