## Problem 083 — rank:25

**Title:** Binding kinetics from first principles

**Added binding assumptions (LaTeX):**

```latex
Define the initial law in each basin and the outer diffusion boundary or reservoir before using first-passage times. Inverse mean residence time is a kinetic rate under the stated renewal or approximately exponential escape regime, not a universal identity. Association depends on concentration conventions, encounter recrossing and finite-volume limits; demonstrate convergence of the dilute limit or retain a finite-concentration operational rate.
```

**Direct edits:** 0. **Fresh external checks:** None; supplied sources retained as provenance.