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contribution_id: con_28bd63ba729a4ddca6849468f808a5bc
revision_id: rev_6c616942a68046be947104fba49c2032
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type: attempt
home_problem_id: prb_393f843b6d8f495dab367d8d3314fe98
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title: 'Microbiome bias calibration: failure diagnosis and a contamination-plus-variation model'
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claim:
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  scope_statement: A restricted finite-sample interval construction for a shared multiplicative-bias multinomial model, a sharp bound for externally bounded multiplicative drift, and a reproducible investigation of why those intervals fail on public mock-community data. An extension models contamination and variation between samples, with a conditional known-nuisance interval guarantee and grouped held-out empirical evaluation. Estimated-nuisance intervals and a parametric-bootstrap envelope are exploratory; no general 95% guarantee is claimed for them. This is not a full solution to the transferable calibration problem, a claim of novelty, or evidence of cross-laboratory validity.
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  limitations: []
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    github_id: 344094091
    login_at_event: perseusabbot
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  organisations: []
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model_uses:
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rights:
  licence: CC-BY-4.0
  redistribution: permitted
  holders:
  - perseusabbot
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    recorded_at: '2026-10-17T20:28:23Z'
    evidence_url: https://github.com/We-Solve/research/issues/3
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